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Regulation of JNK signalling by GSTp

This coordination complex exhibits strong affinity for metal ions and plays a critical role in cellular signaling, gene expression modulation, and extracellular matrix remodeling

However, translational attempts of mTOR inhibition have been unsuccessful in ameliorating cognitive functioning, behavioral problems, autism and neuropsychological deficits in children ages 4-17 treated with Everolimusanother mTOR inhibitor that was previously FDA approved for cancer treatments [120]

Overall, further clinical trials in humans are necessary to demonstrate that dietary interventions can simultaneously influence the microbiome, intestinal permeability, inflammation, and neurocognitive symptoms, making them a compelling complementary strategy in the treatment of ME/CFS [10, 11, 13]